Abstract | BACKGROUND: METHODS: 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide- silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. RESULTS: Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm(2), 4.90 cm(2), 3.12 cm(2), 1.84 cm(2); Mepitel (n=6): 10.29 cm(2), 5.53 cm(2), 3.63 cm(2), 2.02 cm(2); at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. CONCLUSIONS: BPM is comparable to Mepitel as a safe and efficacious wound dressing.
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Authors | Elijah Zhengyang Cai, Erin Yiling Teo, Lim Jing, Yun Pei Koh, Tan Si Qian, Feng Wen, James Wai Kit Lee, Eileen Chor Hoong Hing, Yan Lin Yap, Hanjing Lee, Chuen Neng Lee, Swee-Hin Teoh, Jane Lim, Thiam Chye Lim |
Journal | Archives of plastic surgery
(Arch Plast Surg)
Vol. 41
Issue 6
Pg. 638-46
(Nov 2014)
ISSN: 2234-6163 [Print] Korea (South) |
PMID | 25396174
(Publication Type: Journal Article)
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