HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Bio-conjugated polycaprolactone membranes: a novel wound dressing.

AbstractBACKGROUND:
The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
METHODS:
16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
RESULTS:
Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm(2), 4.90 cm(2), 3.12 cm(2), 1.84 cm(2); Mepitel (n=6): 10.29 cm(2), 5.53 cm(2), 3.63 cm(2), 2.02 cm(2); at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
CONCLUSIONS:
BPM is comparable to Mepitel as a safe and efficacious wound dressing.
AuthorsElijah Zhengyang Cai, Erin Yiling Teo, Lim Jing, Yun Pei Koh, Tan Si Qian, Feng Wen, James Wai Kit Lee, Eileen Chor Hoong Hing, Yan Lin Yap, Hanjing Lee, Chuen Neng Lee, Swee-Hin Teoh, Jane Lim, Thiam Chye Lim
JournalArchives of plastic surgery (Arch Plast Surg) Vol. 41 Issue 6 Pg. 638-46 (Nov 2014) ISSN: 2234-6163 [Print] Korea (South)
PMID25396174 (Publication Type: Journal Article)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: