Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: In March 2014, we conducted a computerized search of MEDLINE and EMBASE for reports on anesthesia and endovascular treatment of acute ischemic stroke. Using random-effects meta-analysis, we evaluated the following outcomes: recanalization rate, good functional outcome (mRS ≤ 2), asymptomatic and symptomatic intracranial hemorrhage, death, vascular complications, respiratory complications, procedure time, time to groin, and time from symptom onset to recanalization. RESULTS: Nine studies enrolling 1956 patients (814 with general anesthesia and 1142 with conscious sedation) were included. Compared with patients treated by using conscious sedation during stroke intervention, patients undergoing general anesthesia had higher odds of death (OR = 2.59; 95% CI, 1.87-3.58) and respiratory complications (OR = 2.09; 95% CI, 1.36-3.23) and lower odds of good functional outcome (OR = 0.43; 95% CI, 0.35-0.53) and successful angiographic outcome (OR = 0.54; 95% CI, 0.37-0.80). No difference in procedure time (P = .28) was seen between the groups. Preintervention NIHSS scores were available from 6 studies; in those, patients receiving general anesthesia had a higher average NIHSS score. CONCLUSIONS:
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Authors | W Brinjikji, M H Murad, A A Rabinstein, H J Cloft, G Lanzino, D F Kallmes |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 36
Issue 3
Pg. 525-9
(Mar 2015)
ISSN: 1936-959X [Electronic] United States |
PMID | 25395655
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | © 2015 by American Journal of Neuroradiology. |
Topics |
- Anesthesia, General
- Brain Ischemia
(drug therapy, surgery, therapy)
- Cerebral Angiography
- Conscious Sedation
- Endovascular Procedures
(methods)
- Humans
- Recovery of Function
- Stroke
(drug therapy, physiopathology, surgery, therapy)
- Thrombectomy
- Thrombolytic Therapy
(methods)
- Treatment Outcome
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