Serum 25-Hydroxyvitamin D and Parathyroid Hormone Levels in Non-Lactating Women with Post-Partum Thyroiditis: The Effect of L-Thyroxine Treatment.

Abstract

Vitamin D deficiency seems to be implicated in the onset and progression of some autoimmune disorders. No previous study has investigated vitamin D homeostasis in post-partum thyroiditis. We compared 25-hydroxyvitamin D and parathyroid hormone (PTH) levels between four groups of non-lactating women who gave birth within 12 months before the beginning of the study: hypothyroid women with post-partum thyroiditis (group A; n = 14), euthyroid females with post-partum thyroiditis (group B; n = 14), women with non-autoimmune hypothyroidism (group C; n = 16) and healthy euthyroid females without thyroid autoimmunity (group D; n = 15). In the second part of the study, groups A and C were treated for 6 months with L-thyroxine. Serum levels of 25-hydroxyvitamin D were lower, while PTH higher in patients with post-partum thyroiditis than in patients without thyroid autoimmunity. They were also lower (25-hydroxyvitamin D) or higher (PTH) in group A than in group B, as well as in group C in comparison with group D. L-thyroxine treatment increased 25-hydroxyvitamin D and reduced PTH levels only in hypothyroid women with post-partum thyroiditis. Baseline levels of 25-hydroxyvitamin D correlated with thyroid antibody titres, thyroid function and circulating PTH levels, while the effect of L-thyroxine on serum levels of this vitamin correlated with the changes in thyroid antibody titres and PTH levels. The results of our study suggest the association of vitamin D status with post-partum thyroiditis and L-thyroxine treatment of this disorder.

• Authors: Robert Krysiak, Beata Kowalska, Bogusław Okopien
• Journal: Basic & clinical pharmacology & toxicology (Basic Clin Pharmacol Toxicol) Vol. 116 Issue 6 Pg. 503-7 (Jun 2015) ISSN: 1742-7843 [Electronic] England
• PMID: 25395280 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

Chemical References

• Parathyroid Hormone
• Phosphates
• Triiodothyronine
• Vitamin D
• Thyrotropin
• 25-hydroxyvitamin D
• Thyroxine
• Calcium

Topics

• Adult
• Aging (metabolism)
• Body Weight
• Calcium (metabolism)
• Female
• Humans
• Lactation
• Parathyroid Hormone (blood)
• Phosphates (metabolism)
• Postpartum Thyroiditis (blood, drug therapy)
• Smoking (metabolism)
• Thyroid Function Tests
• Thyrotropin (blood)
• Thyroxine (adverse effects, blood, therapeutic use)
• Triiodothyronine (blood)
• Vitamin D (analogs & derivatives, blood)
• Young Adult