Effects of omega-3 on metabolic markers in postmenopausal women with metabolic syndrome.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the effect of diet alone or combined with omega-3 supplementation on metabolic and inflammatory markers in postmenopausal women with metabolic syndrome.

METHODS:

This randomized, controlled trial included 87 Brazilian women (age ≥ 45 years and with amenorrhea ≥ 12 months). Exclusion criteria were: cardiovascular disease, insulin-dependent diabetes, cancer, autoimmune diseases and use of either statins or hormone therapy. Participants were randomized to diet alone (n = 43, control) or diet plus omega-3 supplementation, 900 mg/day orally (n = 44). All women were provided with an individualized dietary prescription. Clinical, anthropometrical (body mass index and waist circumference) and biochemical variables were measured. The inflammatory profile included C-reactive protein, tumor necrosis factor α and interleukins (IL-1β and IL-6). The intervention time was 6 months, with assessments at initiation and completion. Data were analyzed according to intention-to-treat, using the independent t-test and ANOVA.

RESULTS:

There were significant reductions in body mass index and waist circumference in both groups (p < 0.05) without significant changes in body fat or muscle mass. Intervention with diet plus omega-3 was associated with significant reduction in systolic (< 12.2%) and diastolic (< 8.2%) blood pressure, serum triglyceride concentration (< 21.4%), and insulin resistance (< 13.1%) (p < 0.05), as well as a reduction in serum IL-6 concentration (< 28.5%) (p = 0.034).

CONCLUSION:

In postmenopausal women with metabolic syndrome, dietary intervention plus supplementation of omega-3 resulted in a further decrease in triglycerides and blood pressure and also in an improvement in insulin resistance and inflammatory markers, important components of metabolic syndrome.

• Authors: A P Tardivo, J Nahas-Neto, C L Orsatti, F B Dias, P F Poloni, E B Schmitt, E A P Nahas
• Journal: Climacteric : the journal of the International Menopause Society (Climacteric) Vol. 18 Issue 2 Pg. 290-8 (Apr 2015) ISSN: 1473-0804 [Electronic] England
• PMID: 25394692 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Fatty Acids, Omega-3
• Interleukin-1beta
• Interleukin-6
• Tumor Necrosis Factor-alpha
• C-Reactive Protein

Topics

• Biomarkers (analysis)
• Blood Pressure
• Body Mass Index
• Brazil
• C-Reactive Protein (analysis)
• Diet
• Dietary Supplements
• Fatty Acids, Omega-3 (administration & dosage)
• Female
• Humans
• Insulin Resistance
• Interleukin-1beta (blood)
• Interleukin-6 (blood)
• Metabolic Syndrome (physiopathology, therapy)
• Middle Aged
• Tumor Necrosis Factor-alpha (blood)
• Waist Circumference