Abstract | PURPOSE OF REVIEW: RECENT FINDINGS:
Azole antifungal treatment in CGD has improved survival. With prolonged survival, inflammatory complications are an emerging problem in CGD. Several studies now present excellent results with stem cell transplantation in severe CGD, also with reduced intensity conditioning. SUMMARY: Several lines of evidence now suggest that stem cell transplantation should be the preferred treatment of choice in severe CGD, if there is an available donor. This should be performed as soon as possible to avoid severe sequelae from infection and inflammation.
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Authors | Anders Åhlin, Anders Fasth |
Journal | Current opinion in hematology
(Curr Opin Hematol)
Vol. 22
Issue 1
Pg. 41-5
(Jan 2015)
ISSN: 1531-7048 [Electronic] United States |
PMID | 25394312
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Allografts
- Antifungal Agents
(therapeutic use)
- Azoles
(therapeutic use)
- Granulomatous Disease, Chronic
(mortality, pathology, therapy)
- Hematopoietic Stem Cell Transplantation
- Humans
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