Abstract | BACKGROUND: Acute myocardial infarction is the first cause of morbidity and mortality in the world, resulting in the combination of genetic and environmental factors. It has been postulated that the R353Q polymorphism of the coagulation FVII gene represents a protective factor for acute myocardial infarction, whereas the N700S polymorphism in the thrombospondin-1 gene is associated with an increased risk for acute myocardial infarction; however, the results are still contradicted. The objective of the study was to examine the possible association of the FVII R353Q and N700S polymorphism and acute myocardial infarction in Mexican patients with acute myocardial infarction younger than 45 years old. METHODS: Case-control study that included 252 patients who were diagnosed with acute myocardial infarction and 252 apparently healthy, age- and gender-matched individuals without a history of coronary artery disease. R353Q and N700S polymorphisms were determined in all participants by PCR-RFLP. RESULTS: CONCLUSIONS: Polymorphisms R353Q and N700S do not represent a protective or risk factor for acute myocardial infarction in young Mexican individuals.
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Authors | María Guadalupe Valades-Mejía, María Lilia Domínguez-López, José Luis Aceves-Chimal, Alfredo Leaños Miranda, Abraham Majluf-Cruz, Irma Isordia-Salas |
Journal | Cirugia y cirujanos
(Cir Cir)
2014 Nov-Dec
Vol. 82
Issue 6
Pg. 595-606
ISSN: 2444-054X [Electronic] Mexico |
Vernacular Title | Estudio de los polimorfismos R353Q en el gen del factor VII de la coagulación y el N700S en el gen de la trombospondina-1 en pacientes jóvenes mexicanos con infarto agudo de miocardio. |
PMID | 25393858
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Thrombospondin 1
- Factor VII
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Topics |
- Adult
- Age Factors
- Case-Control Studies
- Factor VII
(genetics)
- Female
- Humans
- Male
- Mexico
- Myocardial Infarction
(genetics)
- Polymorphism, Genetic
- Thrombospondin 1
(genetics)
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