Abstract | PURPOSE: METHODS: A retrospective case report. RESULTS: A 63-year-old man with acute SMH secondary to polypoidal choroidal vasculopathy underwent a partial posterior vitrectomy, a subretinal tenecteplase (100 μg/0.1 mL) injection with air/fluid exchange, and an intravitreal injection of bevacizumab (2.5 mg/0.1 mL). His preoperative corrected visual acuity was 20/30, but the SMH threatened the fovea. The SMH was displaced inferiorly and absorbed completely at 1 month postoperative. His visual acuity decreased to 20/40 1 week postoperative but recovered to 20/20 2 months after surgery. The electroretinogram showed no distinct elongation of implicit time and slightly decreased amplitude of a-wave and b-wave at 3 months postoperative; optical coherence tomography presented disruption of the inner segment/outer segment line at the onset of SMH but recovered completely at 3 months postoperative. CONCLUSION: Subretinal tenecteplase was found to have sufficient hemolytic function and no retinal toxicity and could represent a feasible treatment option for the management of SMH.
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Authors | Yoon H Kwon, Su J Lim, Woo J Jeung, Yong S You, Soon H Kim, Oh W Kwon |
Journal | Retinal cases & brief reports
(Retin Cases Brief Rep)
Vol. 6
Issue 4
Pg. 400-5
( 2012)
ISSN: 1935-1089 [Print] United States |
PMID | 25389941
(Publication Type: Journal Article)
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