Abstract | STUDY DESIGN: Single-center retrospective study. OBJECTIVE: SUMMARY OF BACKGROUND DATA:
CMCT is a useful and noninvasive measure for evaluating the central motor pathway. However, a systematic correlation between CMCT findings and the responsible level of CCM has so far not been addressed in a large patient cohort. METHOD: We measured CMCT in 75 patients with CCM who were determined by intraoperative spinal cord evoked potentials to have a single site of conduction abnormality at the intervertebral level. Twenty-one healthy controls were also evaluated. Motor evoked potentials, compound muscle action potentials, and F wave were recorded from bilateral abductor digiti minimi (ADM) and abductor hallucis (AH) muscles. CMCT was calculated as follows: motor evoked potentials latency-(CMAPs latency+F latency-1)/2 (ms). RESULT: The mean values of ADM- CMCT and AH- CMCT at each responsible level were significantly longer than those of normal values (P<0.01). However, the mean value of ADM- CMCT at the C6-C7 level was markedly shorter than those at the other levels, whereas the mean values of AH- CMCT were not significantly different between each responsible level. We determined that an ADM- CMCT longer than 7.9 ms (mean+2.5 standard deviation) was abnormal. Using this definition, the sensitivity of ADM- CMCT for CCM was 92% for C3-C4 myelopathy, 95% for C4-C5, 58% for C5-C6, and 9% for C6-C7. CONCLUSION: ADM- CMCT is useful for the screening of CCM rostral to the C5-C6 level. Diagnosis of patients with C6-C7 myelopathy should include assessment of the AH- CMCT. LEVEL OF EVIDENCE: 4.
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Authors | Masahiro Funaba, Tsukasa Kanchiku, Yasuaki Imajo, Hidenori Suzuki, Yuichiro Yoshida, Norihiro Nishida, Toshihiko Taguchi |
Journal | Spine
(Spine (Phila Pa 1976))
Vol. 40
Issue 3
Pg. E161-7
(Feb 01 2015)
ISSN: 1528-1159 [Electronic] United States |
PMID | 25384053
(Publication Type: Journal Article)
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Topics |
- Aged
- Electric Stimulation
- Electrodiagnosis
- Evoked Potentials, Motor
(physiology)
- Female
- Humans
- Male
- Middle Aged
- Muscle, Skeletal
- Retrospective Studies
- Spinal Cord Compression
(diagnosis, physiopathology)
- Transcranial Magnetic Stimulation
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