Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection.

Abstract

The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.

• Authors: Mohamed F Mohamed, Mohamed N Seleem
• Journal: Drug design, development and therapy (Drug Des Devel Ther) Vol. 8 Pg. 1979-83 ( 2014) ISSN: 1177-8881 [Electronic] New Zealand
• PMID: 25378910 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antimicrobial Cationic Peptides

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Antimicrobial Cationic Peptides (pharmacology)
• Disease Models, Animal
• Female
• Methicillin-Resistant Staphylococcus aureus (drug effects, isolation & purification)
• Mice
• Mice, Inbred BALB C
• Microbial Sensitivity Tests
• Staphylococcal Skin Infections (drug therapy, microbiology)