Abstract |
There has been intense interest in developing inhibitors of the sodium channel Nav1.7 because genetic studies have established very strong validation for the efficacy to alleviate both inflammatory and neuropathic pain. This review summarizes patent applications targeting Nav1.7 since 2010 until May, 2014. We have classified the patents into three categories as follows: small molecules with well-defined molecular selectivity among sodium channel isoforms; biologicals with well-defined molecular selectivity; and, small molecules that inhibit Nav1.7 with unknown molecular selectivity. Most of the review is dedicated to small molecule selective compounds.
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Authors | Shaoyi Sun, Charles J Cohen, Christoph M Dehnhardt |
Journal | Pharmaceutical patent analyst
(Pharm Pat Anal)
Vol. 3
Issue 5
Pg. 509-21
(Sep 2014)
ISSN: 2046-8962 [Electronic] England |
PMID | 25374320
(Publication Type: Journal Article, Review)
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Chemical References |
- NAV1.7 Voltage-Gated Sodium Channel
- SCN9A protein, human
- Voltage-Gated Sodium Channel Blockers
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Topics |
- Drug Approval
(statistics & numerical data)
- Drug Industry
(legislation & jurisprudence)
- Humans
- Molecular Structure
- NAV1.7 Voltage-Gated Sodium Channel
(genetics, metabolism)
- Patents as Topic
(statistics & numerical data)
- Voltage-Gated Sodium Channel Blockers
(chemistry, pharmacology)
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