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Significant macular edema in a patient with cone dystrophy and improvement with acetazolamide treatment.

AbstractPURPOSE:
To describe a unique presentation and treatment course of a patient with an established diagnosis of cone dystrophy.
METHODS:
Clinical examination, spectral domain optical coherence tomography, autofluorescence, fluorescein angiography, and electrophysiology testing were evaluated.
RESULTS:
A patient with cone dystrophy diagnosed by clinical examination and electrophysiology testing displayed a large amount of macular intraretinal and subretinal fluid on spectral domain optical coherence tomography in both eyes, without obvious angiographic leakage. Intraretinal fluid resolved after 7 weeks treatment on oral acetazolamide therapy. The patient had subjective improvement in peripheral vision, though the visual acuity remained the same.
CONCLUSION:
Patients with cone dystrophy can accumulate intraretinal edema in the macula, which may respond to carbonic anhydrase therapy.
AuthorsSusan K Gelman, Michael B Gorin
JournalRetinal cases & brief reports (Retin Cases Brief Rep) Vol. 8 Issue 4 Pg. 300-5 ( 2014) ISSN: 1937-1578 [Electronic] United States
PMID25372533 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Carbonic Anhydrase Inhibitors
  • Acetazolamide
Topics
  • Acetazolamide (therapeutic use)
  • Administration, Oral
  • Aged
  • Carbonic Anhydrase Inhibitors (therapeutic use)
  • Humans
  • Macular Edema (drug therapy, etiology)
  • Male
  • Pedigree
  • Retinitis Pigmentosa (complications)
  • Treatment Outcome

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