Morin, a flavonoid, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats.

Abstract

BACKGROUND:

Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the pathology of myocardial infarction.

OBJECTIVE:

The present study was designed to investigate the antioxidant potential of morin, a flavonoid in isoproterenol (ISO)-induced myocardial infarction (MI), in rats.

MATERIALS AND METHODS:

Male albino Wistar rats were pre-treated with morin (40 mg/kg), daily for a period of 30 days. After the treatment period, ISO (85 mg/kg), was subcutaneously injected in rats at an interval of 24 h for 2 days.

RESULTS:

ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide (LOOH), in plasma and heart. Pretreatment with morin, the above changes were significantly reduced to near normal level. ISO-administered rats showed decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in heart. In addition, decrease the levels non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E in plasma and heart while ceruloplasmin in plasma.

CONCLUSION:

Pretreatment with morin, reversed these above biochemical changes towards normalcy. These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity.

• Authors: Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Chinnadurai Veeramani, Ahmed S El Newehy
• Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM (Afr J Tradit Complement Altern Med) Vol. 11 Issue 3 Pg. 14-20 ( 2014) ISSN: 2505-0044 [Electronic] Nigeria
• PMID: 25371558 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Flavonoids
• morin
• Glutathione Peroxidase
• Superoxide Dismutase
• Glutathione

Topics

• Animals
• Antioxidants (metabolism)
• Disease Models, Animal
• Flavonoids (administration & dosage)
• Glutathione (metabolism)
• Glutathione Peroxidase (metabolism)
• Humans
• Lipid Peroxidation (drug effects)
• Male
• Myocardial Infarction (drug therapy, enzymology, metabolism)
• Rats
• Rats, Wistar
• Superoxide Dismutase (metabolism)