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Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-κB pathway activation but not with poor prognosis.

AuthorsS Poglio, X Cahu, B Uzan, C Besnard-Guérin, H Lapillonne, T Leblanc, A Baruchel, J Landman-Parker, A Petit, F Baleydier, S Amsellem, V Baud, P Ballerini, F Pflumio
JournalLeukemia (Leukemia) Vol. 29 Issue 4 Pg. 977-80 (Apr 2015) ISSN: 1476-5551 [Electronic] England
PMID25371179 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • 3-(4-methylphenylsulfonyl)-2-propenenitrile
  • Antineoplastic Agents
  • NF-kappa B
  • Nitriles
  • Oncogene Proteins, Fusion
  • SIL-TAL1 fusion protein, human
  • Sulfones
Topics
  • Adolescent
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Apoptosis (drug effects)
  • Cell Cycle (drug effects)
  • Child
  • Coculture Techniques
  • Gene Expression Regulation, Neoplastic
  • Graft Survival
  • Humans
  • Mice
  • Mice, SCID
  • NF-kappa B (antagonists & inhibitors, genetics, metabolism)
  • Nitriles (pharmacology)
  • Oncogene Proteins, Fusion (genetics, metabolism)
  • Phenotype
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (genetics, metabolism, pathology)
  • Prognosis
  • Signal Transduction
  • Stromal Cells (cytology, metabolism)
  • Sulfones (pharmacology)
  • T-Lymphocytes (metabolism, pathology)
  • Transplantation, Heterologous
  • Xenograft Model Antitumor Assays
  • Young Adult

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