Abstract | AIM: METHODS: A systematic search was conducted in the Medline, Embase, Cochrane Library and China National Knowledge Infrastructure electronic databases. Case-control studies reporting epidural administration of neostigmine and clonidine for labor analgesia were retrieved. For continuous variables, mean differences (MD) and 95% confidence intervals (CI) were calculated; for binary classification variables, odds ratio (OR) and risk ratios (RR) with their 95% CI were analyzed. RESULTS: A total of four case-control studies, including 280 parturients, were identified in this meta-analysis. The results showed that epidural clonidine and neostigmine significantly prolonged initial analgesia (MD = 37.79, 95% CI = 9.37-66.21, P = 0.0.009) and reduced hourly local anesthetics and opioid administration (MD = -5.49, 95% CI = -6.78, -4.21, P < 0.0001). There was no significant difference in total duration of labor, mode of delivery ( cesarean section rate or instrumental delivery rate) and Apgar scores of the neonates in the two groups. CONCLUSION:
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Authors | Ning Zhang, Ming-jun Xu |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 41
Issue 2
Pg. 214-21
(Feb 2015)
ISSN: 1447-0756 [Electronic] Australia |
PMID | 25369869
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology. |
Chemical References |
- Anesthetics, Local
- Neostigmine
- Clonidine
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Topics |
- Anesthesia, Epidural
(methods)
- Anesthesia, Obstetrical
(methods)
- Anesthetics, Local
(administration & dosage, adverse effects)
- Apgar Score
- Clonidine
(administration & dosage)
- Delivery, Obstetric
(methods)
- Female
- Humans
- Infant, Newborn
- Labor Pain
(drug therapy)
- Neostigmine
(administration & dosage)
- Pain Measurement
- Pregnancy
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