An overview of eosinophilic esophagitis.

Abstract

Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease affecting both children and adults. The condition is characterized by an eosinophilic infiltration of the esophageal epithelium. Symptoms of esophageal dysfunction include dysphagia, food impaction and symptoms mimicking gastroesophageal reflux disease. Endoscopic examination typically reveals mucosal fragility, ring or corrugated mucosa, longitudinal furrows, whitish plaques or a small caliber esophagus. Histologic findings of >15 eosinophils per high-power field is the diagnostic hallmark of EoE. An elimination diet, topical corticosteroids or endoscopic dilation for fibrostenotic disease serve as effective therapeutic option.

• Authors: Hyojin Park
• Journal: Gut and liver (Gut Liver) Vol. 8 Issue 6 Pg. 590-7 (Nov 2014) ISSN: 2005-1212 [Electronic] Korea (South)
• PMID: 25368745 (Publication Type: Journal Article, Review)

Chemical References

• Adrenal Cortex Hormones

Topics

• Administration, Topical
• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Child
• Deglutition Disorders (etiology)
• Diagnosis, Differential
• Eosinophilic Esophagitis (complications, diagnosis, therapy)
• Esophageal Stenosis (etiology, surgery)
• Esophagoscopy
• Esophagus (pathology)
• Feeding Behavior
• Gastroesophageal Reflux (diagnosis)
• Humans