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Vincristine-induced blindness: a case report and review of literature.

AbstractBACKGROUND:
Neurotoxicity is a dose-limiting side-effect of vincristine therapy. Blindness is a rare central neurotoxicity of vincristine with few case reports.
CASE REPORT:
In the present article, we report a rare case of vincristine-induced blindness in a patient with diffuse large B cell lymphoma. Literature search identified eleven published cases of vincristine-induced blindness. We reviewed patient characteristics, chemotherapy used and type of blindness.
CONCLUSION:
Vincristine-induced blindness is rare and unpredictable. Prompt recognition and discontinuation of vincristine may lead to recovery of vision.
AuthorsSubodh Adhikari, Raj Man Dongol, Yvonne Hewett, Binay Kumar Shah
JournalAnticancer research (Anticancer Res) Vol. 34 Issue 11 Pg. 6731-3 (Nov 2014) ISSN: 1791-7530 [Electronic] Greece
PMID25368282 (Publication Type: Case Reports, Journal Article, Review)
CopyrightCopyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Chemical References
  • Antibodies, Monoclonal, Murine-Derived
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone
Topics
  • Aged
  • Antibodies, Monoclonal, Murine-Derived (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects)
  • Blindness (chemically induced, pathology)
  • Cyclophosphamide (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Humans
  • Lymphoma, Large B-Cell, Diffuse (drug therapy, pathology)
  • Male
  • Prednisone (administration & dosage)
  • Prognosis
  • Rituximab
  • Vincristine (administration & dosage)

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