Abstract | BACKGROUND: METHODS AND RESULTS: In a randomised, double-blinded, placebo-controlled, cross-over study we measured the forearm blood flow response to the intrabrachial administration of dipyridamole in 14 healthy male subjects before and after treatment with placebo or eplerenone (50 mg bid for 8 days). The forearm blood flow during administration of dipyridamole (10, 30 and 100 µg·min(-1)·dl(-1)) was 1.63 (0.60), 2.13 (1.51) and 2.71 (1.32) ml·dl(-1)·min(-1) during placebo use, versus 2.00 (1.45), 2.68 (1.87) and 3.22 (1.94) ml·dl(-1)·min(-1) during eplerenone treatment (median (interquartile range); P = 0.51). Concomitant administration of the adenosine receptor antagonist caffeine attenuated dipyridamole-induced vasodilation to a similar extent in both groups. The forearm blood flow response to forearm ischemia, as a stimulus for increased formation of adenosine, was similar during both conditions. CONCLUSION: TRIAL REGISTRATION: ClinicalTrials.gov, NCT01837108.
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Authors | T N A van den Berg, Jaap Deinum, Albert Bilos, A Rogier T Donders, Gerard A Rongen, Niels P Riksen |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 10
Pg. e111248
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25356826
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitroprusside
- Spironolactone
- Caffeine
- Dipyridamole
- Eplerenone
- Adenosine
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Topics |
- Adenosine
(biosynthesis)
- Caffeine
(pharmacology)
- Dipyridamole
(pharmacology)
- Double-Blind Method
- Eplerenone
- Forearm
(blood supply)
- Hemodynamics
(drug effects)
- Humans
- Hyperemia
(physiopathology)
- Male
- Nitroprusside
(pharmacology)
- Regional Blood Flow
(drug effects)
- Spironolactone
(administration & dosage, adverse effects, analogs & derivatives, pharmacology)
- Treatment Outcome
- Young Adult
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