Comparative analysis of autologous blood transfusion and allogeneic blood transfusion in surgical patients.

Abstract

OBJECTIVE:

To investigate application effects of autologous blood transfusion and allogeneic blood transfusion in surgically treated patients receiving spine surgery, abdomen surgery and ectopic pregnancy surgery.

METHODS:

130 patients who would undergo selective operations were divided into autologous transfusion group and allogeneic transfusion group. Both groups received the same anesthesia, and there was no significant difference in transfusion volume or fluid infusion volume.

RESULTS:

The serum TNF-α level in autologous transfusion group after operation showed a clear upward trend and had significant difference compared with that before operation (P < 0.05). Meanwhile, after operation, the serum TNF-α level in autologous transfusion group was all significantly higher than that allogeneic transfusion group and the comparative difference was statistically significant (P < 0.05). IgG level in treatment group did not significantly fluctuate during perioperative period, but IgG level in allogeneic transfusion group after operation was all significantly lower than that before operation, and there was statistically significant difference between both groups (P < 0.05). At the same time, complement C3 level in treatment group after operation was significantly higher than that before operation (P < 0.05), but complement C3 level in allogeneic transfusion group did not significantly change. After operation, there was statistically significant difference in complement C3 level between both groups (P < 0.05).

CONCLUSION:

Autologous transfusion is already a widely accepted transfusion method at present, and it can increase TNF-α and complement C3 levels in the body of surgically treated patients to strengthen immune ability against infection.

• Authors: Miao-Yun Long, Zhong-Han Liu, Jian-Guang Zhu
• Journal: International journal of clinical and experimental medicine (Int J Clin Exp Med) Vol. 7 Issue 9 Pg. 2889-94 ( 2014) ISSN: 1940-5901 [Print] United States
• PMID: 25356154 (Publication Type: Journal Article)