Upregulation of Syndecan-1 in the bone marrow microenvironment in multiple myeloma is associated with angiogenesis.

Abstract

OBJECTIVES:

Syndecan-1 (SDC1), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and interleukin-6 (IL6) are expressed by malignant plasma cells and cells in the bone marrow microenvironment and may be involved in the angiogenic process in multiple myeloma (MM).

METHODS:

In this study, we examined the association between bone marrow angiogenesis estimated as micro-vessel density (MVD) and gene expression of SDC1, HGF, VEGF and IL6 in whole bone marrow biopsies from healthy volunteers (n = 10), patients with monoclonal gammopathy of undetermined significance (MGUS) (n = 35) and MM (n = 65).

RESULTS:

MVD was significantly higher in patients with MM than MGUS (P = 0.03) and was positively correlated with plasma cell percentage (P = 0.002). SDC1 gene expression increased with increasing MVD in patients with MGUS and MM (P < 0.001). A positive correlation between bone marrow plasma cell percentage and SDC1 gene expression was detected in patients with MM (P < 0.001). Importantly, after adjustment for plasma cell percentage, the association between MVD and SDC1 gene expression remained significant (P = 0.026). No association between bone marrow angiogenesis and gene expression of HGF, VEGF and IL6 was seen.

CONCLUSION:

Our study indicates that SDC1 expressed by the bone marrow microenvironment is involved in angiogenesis in MM.

• Authors: Niels F Andersen, Ida B Kristensen, Birgitte S Preiss, Jacob H Christensen, Niels Abildgaard
• Journal: European journal of haematology (Eur J Haematol) Vol. 95 Issue 3 Pg. 211-7 (Sep 2015) ISSN: 1600-0609 [Electronic] England
• PMID: 25353275 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Biomarkers
• Syndecan-1

Topics

• Aged
• Aged, 80 and over
• Biomarkers
• Bone Marrow (metabolism, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Middle Aged
• Monoclonal Gammopathy of Undetermined Significance (diagnosis, genetics, metabolism, pathology)
• Multiple Myeloma (diagnosis, genetics, pathology)
• Neovascularization, Pathologic (genetics)
• Syndecan-1 (genetics, metabolism)
• Tumor Microenvironment (genetics)