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Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study.

AbstractCONTEXT AND OBJECTIVE:
Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients.
DESIGN AND SETTING:
Cross-sectional study in a public university hospital.
METHODS:
This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011.
RESULTS:
Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy.
CONCLUSION:
The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence.
AuthorsAline Ventura, Marcelo Fernando Ronsoni, Maria Beatriz Cacese Shiozawa, Esther Buzaglo Dantas-Corrêa, Maria Heloisa Busi da Silva Canalli, Leonardo de Lucca Schiavon, Janaína Luz Narciso-Schiavon
JournalSao Paulo medical journal = Revista paulista de medicina (Sao Paulo Med J) Vol. 132 Issue 6 Pg. 364-71 (Dec 2014) ISSN: 1806-9460 [Electronic] Brazil
PMID25351758 (Publication Type: Journal Article)
Chemical References
  • Autoantibodies
  • Thyrotropin
  • Transglutaminases
Topics
  • Adult
  • Aged
  • Autoantibodies (analysis)
  • Biopsy
  • Brazil (epidemiology)
  • Celiac Disease (complications, epidemiology, pathology)
  • Cross-Sectional Studies
  • Duodenum (pathology)
  • Female
  • Hospitals, Public
  • Hospitals, University
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Seroepidemiologic Studies
  • Thyroiditis, Autoimmune (complications, epidemiology)
  • Thyrotropin (blood)
  • Transglutaminases (immunology)
  • Young Adult

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