Purpose. To study the efficacy of optical internal urethrotomy with
intralesional injection of Vatsala-Santosh PGI tri-inject (
triamcinolone,
mitomycin C, and
hyaluronidase) in the treatment of
anterior urethral stricture. Material and Methods. A total of 103 patients with symptomatic
anterior urethral stricture were evaluated on the basis of clinical history, physical examination, uroflowmetry, and retrograde urethrogram preoperatively. All patients were treated with optical internal urethrotomy followed by injection of tri-inject at the urethrotomy site. Tri-inject was prepared by diluting the combination of
triamcinolone 40 mg,
mitomycin C 2 mg, and
hyaluronidase 3000 in 5-10 mL of saline according to length of
stricture. An indwelling 18 Fr
silicone catheter was left in place for a period of 7-21 days. All patients were followed up for 6-18 months postoperatively on the basis of history, uroflowmetry, and, if required, retrograde urethrogram and micturating urethrogram every 3 months. Results. The overall recurrence rate after first OIU is 19.4% (20 out of 103 patients), that is, a success rate of 80.6%. Overall recurrence rate after second procedure was 5.8% (6 out of 103 patients), that is, a success rate of 94.2%. Conclusion. Optical internal urethrotomy with
intralesional injection of Vatsala-Santosh PGI tri-inject (
triamcinolone,
mitomycin C, and
hyaluronidase) is a safe and effective minimally invasive therapeutic modality for short segment
anterior urethral strictures.