Three suspected cases of sugammadex-induced anaphylactic shock.

Abstract

BACKGROUND:

Sugammadex has a unique mechanism of action and is widely used because of its safety and efficacy. A few recent reports have described allergic reactions to clinical doses of sugammadex. We hereby describe another series of cases of possible anaphylaxis to sugammadex.

CASE PRESENTATION:

We present three suspected cases of sugammadex-induced anaphylactic shock, including a 13-year-old boy who underwent laparoscopic appendectomy, a 75-year-old woman who underwent left knee arthroplasty, and a 34-year-old man who underwent left pansinectomy for sinobronchitis. All three patients received general anesthesia with rocuronium and their tracheas were intubated. Shortly after injection of sugammadex for reversal of rocuronium, all of them experienced a decrease in blood pressure along with mucocutaneous erythema. In the most severe case, reintubation after extubation was required due to difficulty in manual ventilation. All patients recovered with anti-allergic therapy. On later investigation, all three patients had a positive skin reaction to sugammadex.

CONCLUSION:

Our results suggest that physicians using sugammadex should be aware of the possibility of sugammadex-induced anaphylaxis.

• Authors: Tomonori Takazawa, Yukinari Tomita, Nagahide Yoshida, Akihiro Tomioka, Tatsuo Horiuchi, Chie Nagata, Masaki Orihara, Makiko Hardy Yamada, Shigeru Saito
• Journal: BMC anesthesiology (BMC Anesthesiol) Vol. 14 Pg. 92 ( 2014) ISSN: 1471-2253 [Print] England
• PMID: 25349529 (Publication Type: Case Reports, Journal Article)

Chemical References

• Androstanols
• Neuromuscular Nondepolarizing Agents
• gamma-Cyclodextrins
• Sugammadex
• Rocuronium

Topics

• Adolescent
• Adult
• Aged
• Anaphylaxis (etiology)
• Androstanols
• Appendectomy (adverse effects)
• Arthroplasty, Replacement, Knee (adverse effects)
• Drug Hypersensitivity (complications, diagnosis)
• Female
• Humans
• Male
• Neuromuscular Nondepolarizing Agents
• Paranasal Sinuses (surgery)
• Rocuronium
• Sugammadex
• gamma-Cyclodextrins (adverse effects)