HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants.

AbstractOBJECTIVE:
Prophylactic indomethacin reduces severe intraventricular hemorrhage but may increase spontaneous intestinal perforation (SIP) in extremely low birth weight (ELBW) infants. Early feedings improve nutritional outcomes but may increase the risk of SIP. Despite their benefits, use of these therapies varies largely by physician preferences in part because of the concern for SIP.
METHODS:
This was a cohort study of 15,751 ELBW infants in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network from 1999 to 2010 who survived beyond 12 hours after birth. The risk of SIP was compared between groups of infants with and without exposure to prophylactic indomethacin and early feeding in unadjusted analyses and in analyses adjusted for center and for risks of SIP.
RESULTS:
Among infants exposed to prophylactic indomethacin, the risk of SIP did not differ between the indomethacin/early-feeding group compared with the indomethacin/no-early-feeding group (adjusted relative risk [RR] 0.74, 95% confidence interval [CI] 0.49-1.11). The risk of SIP was lower in the indomethacin/early-feeding group compared with the no indomethacin/no-early-feeding group (adjusted RR 0.58, 95% CI 0.37-0.90, P = .0159). Among infants not exposed to indomethacin, early feeding was associated with a lower risk of SIP compared with the no early feeding group (adjusted RR 0.53, 95% CI 0.36-0.777, P = .0011).
CONCLUSIONS:
The combined or individual use of prophylactic indomethacin and early feeding was not associated with an increased risk of SIP in ELBW infants.
AuthorsJohn Kelleher, Ariel A Salas, Ramachandra Bhat, Namasivayam Ambalavanan, Shampa Saha, Barbara J Stoll, Edward F Bell, Michele C Walsh, Abbot R Laptook, Pablo J Sánchez, Seetha Shankaran, Krisa P VanMeurs, Ellen C Hale, Nancy S Newman, M Bethany Ball, Abhik Das, Rosemary D Higgins, Myriam Peralta-Carcelen, Waldemar A Carlo, GDB Subcommittee, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JournalPediatrics (Pediatrics) Vol. 134 Issue 5 Pg. e1369-77 (Nov 2014) ISSN: 1098-4275 [Electronic] United States
PMID25349317 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2014 by the American Academy of Pediatrics.
Chemical References
  • Indomethacin
Topics
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Indomethacin (administration & dosage)
  • Infant, Extremely Low Birth Weight (growth & development)
  • Infant, Newborn
  • Intestinal Perforation (diagnosis, prevention & control)
  • Male
  • Prospective Studies
  • Retrospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: