Prognosis for endometrial cancer patients treated with systematic pelvic and para-aortic lymphadenectomy followed by platinum-based chemotherapy.

Abstract

OBJECTIVE:

The purpose of this study was to analyze the prognosis for endometrial cancer patients treated with systematic pelvic and para-aortic lymphadenectomy (PLA and PALA) followed by platinum-based chemotherapy.

MATERIALS AND METHODS:

From 1994 to 2004, in the Cancer Institute Hospital, 502 patients who were surgically treated with systematic PLA and PALA were enrolled in this study. Their prognosis and clinicopathological features were retrospectively reviewed.

RESULTS:

One hundred ninety-one (38.0%) patients received adjuvant platinum-based chemotherapy. Lymph node (LN) metastasis was observed in 80 (15.9%) patients, pelvic-only LN metastasis in 27 (5.4%), para-aortic-only LN metastasis in 15 (3.0%), and both pelvic and para-aortic LN metastasis in 38 (7.6%). The median number of metastatic LNs was 2 (range, 1-57), 1 (range, 1-4), and 6 (range, 2-50) in patients with pelvic-only, para-aortic-only, and both pelvic and para-aortic LN metastasis, respectively (P < 0.001). Only 2.6% (2/76) of patients with no myometrial invasion had LN metastasis, and no less than 8.9% (22/247) of patients with myometrial invasion (limited to the inner half) had LN metastasis. Five-year overall survival (OS) for LN metastasis-negative and -positive patients was 96.7% and 76% (P < 0.001), respectively. Five-year OS for patients with metastasis in 1 or 2 LNs was 84.8% and was significantly higher than that for patients with metastasis in 3 or more LNs (57.8%; P = 0.011). In patients with LN metastasis, 5-year OS of endometrioid adenocarcinoma and non-endometrioid adenocarcinoma cell types was 90.2% and 56.7% (P = 0.0016), respectively.

CONCLUSIONS:

Under the settings of thorough PLA and PALA followed by intensive platinum-based chemotherapy for endometrial cancer, metastasis in 1 or 2 LNs seems to have little effect on survival, although para-aortic LNs are involved. This therapeutic strategy could not improve the prognosis of patients with metastasis in 3 or more LNs or patients with non-endometrioid adenocarcinoma cell types along with LN involvement.

• Authors: Kotaro Sueoka, Kenji Umayahara, Akiko Abe, Tomoka Usami, Akiko Yamamoto, Hidetaka Nomura, Maki Matoda, Sanshiro Okamoto, Kohei Omatsu, Eiji Kondo, Kazuyoshi Kato, Nobuhiro Takeshima
• Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (Int J Gynecol Cancer) Vol. 25 Issue 1 Pg. 81-6 (Jan 2015) ISSN: 1525-1438 [Electronic] England
• PMID: 25347094 (Publication Type: Journal Article)

Chemical References

• Doxorubicin
• Cyclophosphamide
• Carboplatin
• Paclitaxel
• Cisplatin
• Ifosfamide

Topics

• Adenocarcinoma, Clear Cell (mortality, secondary, therapy)
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carboplatin (administration & dosage)
• Carcinoma, Endometrioid (mortality, secondary, therapy)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Cystadenocarcinoma, Serous (mortality, secondary, therapy)
• Doxorubicin (administration & dosage)
• Endometrial Neoplasms (mortality, pathology, therapy)
• Female
• Follow-Up Studies
• Humans
• Ifosfamide (administration & dosage)
• Lymph Node Excision
• Lymph Nodes (pathology, surgery)
• Lymphatic Metastasis
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (mortality, pathology, therapy)
• Neoplasm Staging
• Paclitaxel (administration & dosage)
• Para-Aortic Bodies (pathology)
• Pelvic Neoplasms (mortality, secondary, therapy)
• Prognosis
• Retrospective Studies
• Survival Rate
• Young Adult