Abstract | BACKGROUND: METHODS: RESULTS: Among 55 patients, 40 patients had high serum alanine aminotransferase (ALT) level (≧38 IU/l). Blood platelet count after splenectomy of patients with high serum ALT level were significantly lower than those of patients with low serum ALT level (P = 0.02). Histopathologically, platelet area of the liver tissues was positively correlated with hepatic inflammation (P = 0.02). Platelet area of the liver tissues was negatively correlated with blood platelet count after splenectomy (P = 0.03). CONCLUSIONS: Hepatic inflammation contributes to the accumulation of platelets in liver; therefore, in patients with high serum ALT level, improvement of thrombocytopenia by the elimination of hypersplenism was limited.
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Authors | Reiichiro Kondo, Masayoshi Kage, Toshiro Ogata, Osamu Nakashima, Jun Akiba, Yoriko Nomura, Hirohisa Yano |
Journal | Journal of hepato-biliary-pancreatic sciences
(J Hepatobiliary Pancreat Sci)
Vol. 22
Issue 3
Pg. 217-24
(Mar 2015)
ISSN: 1868-6982 [Electronic] Japan |
PMID | 25345682
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Japanese Society of Hepato-Biliary-Pancreatic Surgery. |
Topics |
- Adult
- Aged
- Biopsy
- Female
- Follow-Up Studies
- Hepatitis
(etiology, pathology)
- Humans
- Hypersplenism
(complications, surgery)
- Liver
(pathology)
- Liver Cirrhosis
(complications, surgery)
- Male
- Middle Aged
- Necrosis
(etiology, pathology)
- Retrospective Studies
- Splenectomy
(methods)
- Treatment Outcome
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