Monitoring parotid gland tumors with a new perfusion software for contrast-enhanced ultrasound.

Abstract

PURPOSE:

Contrast enhanced ultrasound (CE-US) is a promising imaging modality for non-invasive analysis of functional vascularisation. Lesions of the parotid gland are associated with a vascularisation that differs from normal gland tissue. The aim of this clinical study was to further analyse the perfusion in parotid gland lesions with CE-US. The new quantification software VueBox (Bracco, Italy) was used to assess the perfusion, based on DICOM datasets of CE-US examination.

MATERIALS AND METHODS:

CE-US measurements were performed by intravenous application of a contrast agent (SonoVue, Bracco, Italy) before surgical tumor resection. From the analysis of a time sequence of 2D DICOM contrast images, area under time intensity curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in-perfusion-index (WiPI) were calculated using VueBox. These were correlated with the histological analyses of the tumor tissue.

RESULTS:

Significant difference of area below intensity time curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in perfusion index (WiPI) were observed in the malign lesions compared to benign tumors (p < 0,05) and in pleomorphic adenoma compared to cystadenolymphoma (p < 0,05).

CONCLUSION:

CE-US seems to be a quantitative and independent method for discriminating between malign and benign parotid gland tumors.

• Authors: Laura V Klotz, Michael Ingrisch, Martin E Eichhorn, Olivier Niemoeller, Vanessa Siedek, Robert Gürkov, Dirk-Andre Clevert
• Journal: Clinical hemorheology and microcirculation (Clin Hemorheol Microcirc) Vol. 58 Issue 1 Pg. 261-9 ( 2014) ISSN: 1875-8622 [Electronic] Netherlands
• PMID: 25339101 (Publication Type: Journal Article)

Chemical References

• Contrast Media

Topics

• Adult
• Aged
• Aged, 80 and over
• Area Under Curve
• Contrast Media (chemistry)
• Female
• Humans
• Lymphoma (pathology)
• Male
• Middle Aged
• Parotid Gland (diagnostic imaging)
• Parotid Neoplasms (diagnosis, diagnostic imaging, pathology)
• Perfusion
• Reproducibility of Results
• Software
• Ultrasonography
• Young Adult