This study was purposed to investigate the cytomegalovirus (CMV)
infection and its related factors after allogenic
hematopoietic stem cell transplantation (allo-HSCT). A total of 108 patients who received allo-HSCT in zhongda hospital from January 1, 2004 to March 31, 2014 were enrolled in this study. The CMV
infection rate and the median time when the CMV-
DNA was positive for the first time, and the risk factors related with CMV
infection, CMV disease distribution and mortality after allo-HSCT were analyzed. The results showed that the
infection rate of CMV was 52.78% (57/108), the median time of CMV
infection was 44 d, especially during 30 d-100 d after
transplantation. The univariate analysis showed that CMV
infection rate was related with the HLA-identical situation between the donor and the recipient, and whether the use of anti-human thymus
globulin(ATG) in conditioning regimen, neutropenic period after
transplantation exceeded 10 d and
graft-versus-host disease (GVHD). Multivariate analysis showed that CMV
infection rate was related with neutropenic period longer than 10 d after
transplantation and
graft-versus-host disease (GVHD). The mortality of the patients with CMV disease was 58.82% (10/17), in which the mortality of CMV
interstitial pneumonia was highest. The CMV
infection was one of the most commonly happened
infection after allo-HSCT. It is concluded that to reduce the incidence of CMV disease and mortality, the best choice of allo-HSCT is HLA-identical donor, ATG should be used during the conditioning process, and neutropenic period should be reduced less than 10 days. Moreover, it is necessary to strengthen the preemptive
therapy of CMV
infection actively.