Abstract | BACKGROUND: METHODS: RESULTS: Uterine weight gain was significantly decreased in ovariectomized PR (cre/+) Pten(f/f) mice compared to intact PR (cre/+) Pten(f/f) mice. Ovariectomized PR (cre/+) Pten(f/f) mice treated with P4 or vehicle also exhibited decreased uterine cancer size compared with intact PR (cre/+) Pten(f/f) mice. Proliferation of ovariectomized PR (cre/+) Pten(f/f) mice treated with P4 is highly decreased compared to other groups. The levels of stromal progesterone receptor were highly increased in ovariectomized PR (cre/+) Pten(f/f) mice treated with P4 which resulted in decreased epithelial proliferation. CONCLUSIONS: These results suggest that P4 treatment significantly reduces tumor mass but does not affect cancer progression in PR (cre/+) Pten(f/f) mice.
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Authors | Hong Im Kim, Tae Hoon Kim, Jeong Mook Lim, Jae-Wook Jeong |
Journal | Journal of cancer prevention
(J Cancer Prev)
Vol. 18
Issue 4
Pg. 313-21
(Dec 2013)
ISSN: 2288-3649 [Print] Korea (South) |
PMID | 25337560
(Publication Type: Journal Article)
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