Abstract | PURPOSE: METHODS: We retrospectively analyzed the distribution of the both HPSE SNPs rs4693608 and rs4364254 and the occurrence of SOS after allogeneic HSCT in 160 children with malignant and non-malignant diseases. RESULTS: Patients with HPSE genotypes GG or AG of rs4693608 (G>A) had a significantly reduced incidence of SOS on day 100 after HSCT compared to patients with genotype AA (4.7 vs. 14.3 %, P = 0.038). In addition, incidence of SOS in patients with genotype CC or CT of rs4364254 (C>T) was significantly decreased in comparison with patients with genotype TT (2.3 vs. 14.7 %, P = 0.004). Interestingly, no patient with genotype CC developed SOS. Because both SNPs co-occur in vivo, we generated subsets: AA-TT, GG-CC, and a group with remaining SNP combinations. We found significant differences between all three patient groups (P = 0.035). Patients with AA-TT showed the highest incidence of SOS (16.7 %), while SOS did not appear in patients with GG-CC (0 %) and residual combinations were numerically in-between (4.9 %). An impact caused by main patient and donor characteristics, established risk factors for SOS, and conditioning regimen could be excluded in multivariate analyses. CONCLUSIONS: HPSE polymorphisms turned out to be significant independent risk factors (P = 0.030) for development of SOS and should be evaluated in further trials.
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Authors | Claudia Seifert, Susan Wittig, Clemens Arndt, Bernd Gruhn |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 141
Issue 5
Pg. 877-85
(May 2015)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 25335953
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Female
- Genotype
- Glucuronidase
(genetics)
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Hepatic Veno-Occlusive Disease
(diagnosis, enzymology, epidemiology, etiology, genetics, mortality)
- Humans
- Incidence
- Infant
- Infant, Newborn
- Kaplan-Meier Estimate
- Male
- Polymerase Chain Reaction
(methods)
- Polymorphism, Single Nucleotide
- Retrospective Studies
- Risk Factors
- Time Factors
- Transplantation Conditioning
(adverse effects)
- Transplantation, Homologous
- Young Adult
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