Abstract |
The neuroprotective properties of the novel glutamic acid derivative neiroglutam have been studied in vitro and in vivo. Neiroglutam demonstrated the protective action on 6-OH-dopamine neurotoxicity model <MI> in vitro, where free radical oxidation is a basic part of pathogenesis. In control rats, focal brain ischemia caused significant increase in thiobarbituric acid reactive species ( TBARS) level and decrease in superoxide dismutase (SOD) enzyme activity. In two-year-old rats, preventive administration of the neiroglutam caused a significant reduction in the TBARS plasma concentration (34.5%, p < 0.05), increased SOD activity, and increased the time of acid-induced hemolysis of erythrocytes (40%, p < 0.05).
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Authors | I N Tiurenkov, E V Volotova, D V Kurkin, D A Bakulin, I O Logvinov, T A Antipova |
Journal | Eksperimental'naia i klinicheskaia farmakologiia
(Eksp Klin Farmakol)
Vol. 77
Issue 8
Pg. 16-9
( 2014)
ISSN: 0869-2092 [Print] Russia (Federation) |
PMID | 25335385
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Free Radicals
- Neuroprotective Agents
- Thiobarbituric Acid Reactive Substances
- Glutamic Acid
- Oxidopamine
- Superoxide Dismutase
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Topics |
- Animals
- Brain Ischemia
(drug therapy, metabolism, pathology)
- Cell Line, Tumor
- Erythrocytes
(drug effects)
- Free Radicals
(antagonists & inhibitors, metabolism)
- Glutamic Acid
(analogs & derivatives, pharmacology)
- Hemolysis
(drug effects)
- Humans
- Male
- Neurons
(cytology, drug effects, metabolism)
- Neuroprotective Agents
(pharmacology)
- Oxidation-Reduction
- Oxidative Stress
- Oxidopamine
(antagonists & inhibitors, pharmacology)
- Rats
- Superoxide Dismutase
(metabolism)
- Thiobarbituric Acid Reactive Substances
(analysis)
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