Total pancreatectomy with islet autotransplantation: summary of a National Institute of Diabetes and Digestive and Kidney diseases workshop.

Abstract

A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases focused on research gaps and opportunities in total pancreatectomy with islet autotransplantation (TPIAT) for the management of chronic pancreatitis (CP). The session was held on July 23, 2014, and structured into 5 sessions: (1) patient selection, indications, and timing; (2) technical aspects of TPIAT; (3) improving success of islet autotransplantation; (4) improving outcomes after total pancreatectomy; and (5) registry considerations for TPIAT. The current state of knowledge was reviewed; knowledge gaps and research needs were specifically highlighted. Common themes included the need to identify which patients best benefit from and when to intervene with TPIAT, current limitations of the surgical procedure, diabetes remission and the potential for improvement, opportunities to better address pain remission, gastrointestinal complications in this population, and unique features of children with CP considered for TPIAT. The need for a multicenter patient registry that specifically addresses the complexities of CP and total pancreatectomy outcomes as well as postsurgical diabetes outcomes was repeatedly emphasized.

• Authors: Melena D Bellin, Andres Gelrud, Guillermo Arreaza-Rubin, Ty B Dunn, Abhinav Humar, Katherine A Morgan, Bashoo Naziruddin, Cristiana Rastellini, Michael R Rickels, Sarah J Schwarzenberg, Dana K Andersen
• Journal: Pancreas (Pancreas) Vol. 43 Issue 8 Pg. 1163-71 (Nov 2014) ISSN: 1536-4828 [Electronic] United States
• PMID: 25333399 (Publication Type: Congress)

Chemical References

• Anti-Inflammatory Agents
• Anticoagulants
• Immunoglobulin G
• Immunosuppressive Agents
• Insulin
• Receptors, Tumor Necrosis Factor
• Heparin
• Etanercept

Topics

• Adult
• Anti-Inflammatory Agents (therapeutic use)
• Anticoagulants (therapeutic use)
• Child
• Diabetes Mellitus, Type 1 (drug therapy, etiology, prevention & control, surgery)
• Etanercept
• Heparin (therapeutic use)
• Humans
• Immunoglobulin G (therapeutic use)
• Immunosuppressive Agents (therapeutic use)
• Insulin (therapeutic use)
• Islets of Langerhans Transplantation (economics, methods, standards)
• National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
• Pancreatectomy (adverse effects, economics, methods)
• Pancreatitis, Chronic (drug therapy, genetics, surgery)
• Patient Selection
• Postoperative Complications (etiology, therapy)
• Quality Improvement
• Quality of Life
• Receptors, Tumor Necrosis Factor (therapeutic use)
• Registries
• Research
• United States
• United States Food and Drug Administration