Abstract | OBJECTIVES: METHODS: Twenty-six maintenance hemodialysis ESRD patients and 28 healthy controls underwent diffusion tensor imaging (DTI), Mini Mental State Examination (MMSE), Trial Marking Test-A&B (TMT-A&B), and white matter hyperintensity (WMH) assessment. Tract-based spatial statistics (TBSS) analyses was performed to evaluate WM changes in the patients. Relationships between behavioural performances, clinical data, and the DTI index were tested, respectively, by correlation analysis at the voxel level. RESULTS:
ESRD patients showed significant decreased fractional anisotropy (FA) in 14 WM regions, and increased mean diffusivity (MD) and radial diffusivity (RD) in widespread regions. Significant positive correlations between FA values and MMSE scores were found in the right anterior corona radiata and the left anterior thalamic radiation; significant negative correlations between the TMT-B time consumption and FA values were identified in the bilateral superior longitudinal fasciculus. Positive linear relationships between MD, RD values, and the duration of hemodialysis were found in several WM regions. CONCLUSION: Structural damages to radiation and associative fibre tracts, caused by brain oedema and WM demyelination, may account for the cognitive deficits in ESRD patients.
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Authors | Ruijie Zhang, Kai Liu, Linfeng Yang, Tao Zhou, Shaowen Qian, Bo Li, Zhaohui Peng, Min Li, Shengpeng Sang, Qingjun Jiang, Gang Sun |
Journal | European radiology
(Eur Radiol)
Vol. 25
Issue 3
Pg. 661-8
(Mar 2015)
ISSN: 1432-1084 [Electronic] Germany |
PMID | 25326436
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Anisotropy
- Brain Edema
(complications)
- Case-Control Studies
- Cognition Disorders
(etiology, pathology)
- Diffusion Tensor Imaging
(methods)
- Female
- Humans
- Kidney Failure, Chronic
(complications, pathology)
- Leukoencephalopathies
(pathology, psychology)
- Male
- Middle Aged
- Neuropsychological Tests
- Renal Dialysis
(adverse effects)
- Young Adult
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