Abstract |
In the present study, the effects of δ- tocopherol (δ-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of α- tocopherol (α-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with δ-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of α-T were modest. The strong effects of δ-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that δ-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of α-T. Moreover, δ-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified δ-T as a better form of vitamin E than α-T for future clinical studies of prostate cancer prevention.
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Authors | Huarong Huang, Yan He, Xiao-Xing Cui, Susan Goodin, Hong Wang, Zhi Yun Du, Dongli Li, Kun Zhang, Ah-Ng Tony Kong, Robert S DiPaola, Chung S Yang, Allan H Conney, Xi Zheng |
Journal | Journal of agricultural and food chemistry
(J Agric Food Chem)
Vol. 62
Issue 44
Pg. 10752-8
(Nov 05 2014)
ISSN: 1520-5118 [Electronic] United States |
PMID | 25322450
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Androgen
- Prostate-Specific Antigen
- delta-tocopherol
- Tocopherols
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Topics |
- Animals
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Humans
- Male
- Mice, SCID
- Prostate-Specific Antigen
(metabolism)
- Prostatic Neoplasms
(drug therapy, metabolism, physiopathology)
- Receptors, Androgen
(metabolism)
- Tocopherols
(administration & dosage)
- Xenograft Model Antitumor Assays
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