Inulin, a group of
dietary fibers, is reported to improve the metabolic disorders. In the present study, we investigated the effects of chicory
inulin on serum metabolites of
uric acid (UA),
lipids,
glucose, and abdominal fat deposition in quail model induced by a
purine-rich diet. In this study, 60 male French quails were randomly allocated to five groups: CON (control group), MOD (model group), BEN (
benzbromarone-treated group), CHI-H (high-dosage chicory
inulin-treated group), and CHI-L (low-dosage chicory
inulin-treated group). The serum UA level was significantly increased in the model group from days 7 to 28, as well as
triglyceride (TG) and
free fatty acid (FFA) increased later in the experimental period. The abdominal fat ratio was increased on day 28.
Benzbromarone can decrease UA levels on days 14 and 28. The high and low dosage of chicory
inulin also decreased serum UA levels on days 7, 14, and 28. The abdominal fat ratio, activity, and
protein of
acetyl-CoA carboxylase (ACC) were decreased in chicory
inulin-treated groups. The activities of
xanthine oxidase (XOD) and
fatty acid synthase (FAS) were increased in the model group and decreased in the
benzbromarone and chicory
inulin groups. This study evaluated a quail model of induced
hyperuricemia with other metabolic disorders caused by a high-
purine diet. The results indicated that a
purine-rich diet might contribute to the development of
hyperuricemia,
hypertriglyceridemia, and
abdominal obesity. Chicory
inulin decreased serum UA, TG, and abdominal fat deposition in a quail model of
hyperuricemia by altering the ACC
protein expression and FAS and XOD activities.