Abstract |
To evaluate haematopoietic stem cell transplantation (HSCT) in children and adolescents, we reviewed the records of 47 patients who were ≤18 years, had relapsed or refractory anaplastic large cell lymphoma, and received HSCT between 1990 and 2010. At HSCT, complete remission (CR) was less common in allogeneic HSCT recipients (n = 24) than in autologous HSCT recipients (n = 23) (P = 0·01). The autologous and allogeneic HSCT groups differed in terms of 5-year event-free survival (EFS) (38% vs. 50%, P = 0·63), cumulative incidence of progress or relapse (49% vs. 28%, P = 0·25), and treatment-related mortality (12% vs. 25%, P = 0·40). However, these differences were not significant. Patients with non-CR at autologous HSCT had a significantly lower EFS rate (14% vs. 48%, P = 0·03). Conversely, although those with non-CR at allogeneic HSCT had a lower EFS rate, this was not significant (44% vs. 63%, P = 0·26). Reduced-intensity conditioning regimens were used for three of the 16 allogeneic HSCTs received by patients with non-CR. These three patients achieved CR, surviving 32-65 months after HSCT. These results demonstrated that allogeneic HSCT might be a treatment option for patients who do not achieve CR through conventional chemotherapy.
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Authors | Reiji Fukano, Tetsuya Mori, Ryoji Kobayashi, Tetsuo Mitsui, Naoto Fujita, Fuminori Iwasaki, Junji Suzumiya, Motoaki Chin, Hiroaki Goto, Yoshiyuki Takahashi, Junichi Hara, Yong-Dong Park, Masami Inoue, Yuhki Koga, Jiro Inagaki, Hisashi Sakamaki, Souichi Adachi, Keisei Kawa, Koji Kato, Ritsuro Suzuki |
Journal | British journal of haematology
(Br J Haematol)
Vol. 168
Issue 4
Pg. 557-63
(Feb 2015)
ISSN: 1365-2141 [Electronic] England |
PMID | 25312752
(Publication Type: Evaluation Study, Journal Article)
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Copyright | © 2014 John Wiley & Sons Ltd. |
Topics |
- Adolescent
- Allografts
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Child
- Combined Modality Therapy
- Disease-Free Survival
- Drug Resistance, Neoplasm
- Graft vs Host Disease
(epidemiology, etiology)
- Hematopoietic Stem Cell Transplantation
- Humans
- Incidence
- Japan
(epidemiology)
- Lymphoma, Large-Cell, Anaplastic
(drug therapy, therapy)
- Recurrence
- Retrospective Studies
- Salvage Therapy
- Transplantation Conditioning
- Transplantation, Autologous
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