Abstract |
We report draft genome sequence of Ochrobactrum intermedium strain 229E concurrent with Helicobacter pylori in urease positive gastric biopsy of non- ulcer dyspeptic individual from Southern part of India. Since the role of Ochrobactrum in human gastric environment is poorly understood, comprehensive pathological, microbiological, and genome level understanding are necessary to evaluate its association with H. pylori in the gastric niche. Comparative analysis of O. intermedium 299E strain revealed functional similarities with virulence related gene clusters present in H. pylori genomes, which probably might aid in its ability to persist in the human gastric mucosa. However, H.pylori specific vacuolating cytotoxin (vacA) involved in vacuolization, cytotoxicity, and T-cell inhibition was absent in the O. intermedium 229E genome. Taken together, O. intermedium 229E shared numerous features like secretion system, urease, and flagella with H.pylori genome sequence that might aid concurrence in the gastric niche.
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Authors | Girish J Kulkarni, Sudarshan Shetty, Mahesh S Dharne, Yogesh S Shouche |
Journal | FEMS microbiology letters
(FEMS Microbiol Lett)
Vol. 359
Issue 1
Pg. 12-5
(Oct 2014)
ISSN: 1574-6968 [Electronic] England |
PMID | 25312622
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved. |
Chemical References |
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Topics |
- DNA, Bacterial
(chemistry, genetics)
- Genome, Bacterial
- India
- Molecular Sequence Data
- Ochrobactrum
(genetics, isolation & purification)
- Sequence Analysis, DNA
- Stomach
(microbiology)
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