Application of nano-carbon in lymph node dissection for thyroid cancer and protection of parathyroid glands.

Abstract

BACKGROUND:

The aim of this study was to explore a new method to identify and protect parathyroid glands in neck lymph node dissection for patients with thyroid cancer.

MATERIAL AND METHODS:

One hundred patients with thyroid cancer underwent total thyroidectomy combined with central neck lymph node dissection. During the operation, 50 patients receiving nano-carbon suspension were included in the experiment group, and 50 patients without nano-carbon suspension were included in the control group. We compared changes in parathyroid hormone levels before surgery and at 48 h after surgery between the 2 groups and of serum Ca^2+ level within 48 h after surgery, as well as postoperative parathyroid pathological and lymph node dissection results.

RESULTS:

Eight and 1 parathyroid glands were detected pathologically in the control and experimental group, respectively. Decrease in parathyroid hormone level at 48 h occurred in 7 patients in the control group and 1 patient in the experimental group. Hypocalcemia was found at 48 h after surgery in 10 patients in the control group and 2 patients in the experimental group.

CONCLUSIONS:

Nano-carbon suspension can cause development of the thyroid gland and the central lymph node and a negative development of parathyroid glands. Careful identification and removal of black-stained lymphatic tissues in the process of total thyroidectomy with neck lymph node dissection can ensure a complete lymph node dissection and prevent parathyroid damage, thus effectively reducing the incidence of hypoparathyroidism.

• Authors: Wuguo Tian, Yan Jiang, Bo Gao, Xiaohua Zhang, Shu Zhang, Jianjie Zhao, Yujun He, Donglin Luo
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 20 Pg. 1925-30 (Oct 14 2014) ISSN: 1643-3750 [Electronic] United States
• PMID: 25311844 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbon

Topics

• Adult
• Carbon (chemistry)
• Female
• Humans
• Lymph Node Excision (methods)
• Male
• Middle Aged
• Nanostructures
• Parathyroid Glands (pathology)
• Thyroid Neoplasms (pathology, surgery)
• Young Adult