Abstract | BACKGROUND/AIMS: METHODS: Nephrectomized mice were assigned to a normal chow diet group (normal chow), a group receiving 1000 mg/kg diet of α- tocopherol supplementation or a group receiving 1000 mg/kg diet mixed- tocopherol (60% γ- tocopherol). RESULTS: Following 12 weeks, in vitro aortic endothelial-independent relaxation was enhanced with both α- tocopherol and mixed- tocopherol (P < 0.05), while mixed- tocopherol enhanced aortic contraction at noradrenaline concentrations of 3 × 10(-7) M to 3 × 10(-5) M (P < 0.05), when compared to normal chow. Supplementation with α- and mixed- tocopherol reduced systemic concentrations of IL-6 (P < 0.001 and P < 0.001, respectively) and IL-10 (P < 0.05 and P < 0.001, respectively), while α- tocopherol also reduced MCP-1 (P < 0.05) and tumor necrosis factor (TNF)-α (P < 0.05). Aortic sinus plaque area was significantly reduced with α- tocopherol supplementation when compared to normal chow (P < 0.01). CONCLUSION:
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Authors | Cecilia M Shing, Robert G Fassett, Jonathan M Peake, Jeff S Coombes |
Journal | Cardiovascular therapeutics
(Cardiovasc Ther)
Vol. 32
Issue 6
Pg. 270-5
(Dec 2014)
ISSN: 1755-5922 [Electronic] England |
PMID | 25307205
(Publication Type: Journal Article)
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Copyright | © 2014 John Wiley & Sons Ltd. |
Chemical References |
- Antioxidants
- Apolipoproteins E
- Cytokines
- Superoxide Dismutase
- Tocopherols
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Apolipoproteins E
(physiology)
- Atherosclerosis
(prevention & control)
- Cytokines
(blood)
- Endothelium, Vascular
(physiology)
- Inflammation
(prevention & control)
- Male
- Mice
- Nephrectomy
- Renal Insufficiency, Chronic
(complications)
- Superoxide Dismutase
(metabolism)
- Tocopherols
(therapeutic use)
- Vasodilation
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