Abstract |
The neuromodulatory role of serotonin in the anticonvulsant activity of methaqualone was investigated. A dose-dependent increase in the ability of methaqualone to provide protection against pentylenetetrazol (90 mg/kg SC)-induced convulsions in mice was observed. The ED50 value for the anticonvulsant activity of methaqualone was calculated and found to be 60 mg/kg, IP. Pretreatment of mice with 5-hydroxytryptophan (100 mg/kg, IP, 2 hr) and p-chlorophenylalanine (300 mg/kg, IP, 2 hr), causing an increase in brain serotonin levels, resulted in a 60% and 80% increase, respectively, in the anticonvulsant activity of methaqualone. Similar pretreatment with p-chlorophenylalanine (300 mg/kg, IP, 48 hr), causing a lowering of brain serotonin, and methysergide (10 mg/kg, IP, 0.5 hr), causing blockade of brain serotonin receptors, resulted in a 40% and 20% decrease, respectively, in the ability of methaqualone to provide protection against pentylenetetrazol-induced convulsions. These results suggest a facilitatory role of serotonin in the anticonvulsant activity of methaqualone.
|
Authors | M I Leadbetter, S S Parmar |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 46
Issue 1
Pg. 105-6
(Jul 1989)
ISSN: 0031-9384 [Print] United States |
PMID | 2530597
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anticonvulsants
- Receptors, Serotonin
- Serotonin
- Methaqualone
- Tryptophan
- 5-Hydroxytryptophan
- Fenclonine
- Pentylenetetrazole
|
Topics |
- 5-Hydroxytryptophan
(pharmacology)
- Animals
- Anticonvulsants
- Brain
(drug effects)
- Dose-Response Relationship, Drug
- Fenclonine
(pharmacology)
- Male
- Methaqualone
(pharmacology)
- Mice
- Mice, Inbred Strains
- Pentylenetetrazole
(pharmacology)
- Receptors, Serotonin
(drug effects)
- Seizures
(chemically induced, prevention & control)
- Serotonin
(physiology)
- Tryptophan
(pharmacology)
|