Altered sphingoid base profiles in type 1 compared to type 2 diabetes.

Abstract

BACKGROUND:

Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated.

FINDINGS:

We analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-linked headgroups in plasma from individuals with T1DM (N = 27), T2DM (N = 30) and healthy controls (N = 23). 1-deoxySLs were significantly higher in the groups with T2DM but not different between T1DM and controls. In contrast to patients with T2DM, 1-deoxSL levels are not elevated in T1DM.

CONCLUSIONS:

Our study indicates that the 1-deoxySL formation is not per-se caused by hyperglycemia but rather specifically associated with metabolic changes in T2DM, such as elevated triglyceride levels.

• Authors: Nancy Wei, Jessica Pan, Rodica Pop-Busui, Alaa Othman, Irina Alecu, Thorsten Hornemann, Florian S Eichler
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 13 Pg. 161 (Oct 11 2014) ISSN: 1476-511X [Electronic] England
• PMID: 25305670 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Lipids
• Sphingolipids
• Sphingosine
• spisulosine

Topics

• Adult
• Aged
• Case-Control Studies
• Diabetes Mellitus, Type 1 (blood)
• Diabetes Mellitus, Type 2 (blood)
• Female
• Humans
• Lipids
• Male
• Middle Aged
• Sphingolipids (blood)
• Sphingosine (analogs & derivatives, blood)