Abstract | BACKGROUND: Postoperative infection after breast reduction surgery is a common complication, with the most commonly involved pathogen being Staphylococcus aureus. Previous studies of antibiotic prophylaxis in breast reduction surgery have been inconclusive. The aim of the present study was to clarify the role of prophylactic antibiotics in breast reduction surgery. METHODS: RESULTS: In the intervention group, 26 (16.0%) patients were treated with antibiotic; and in the control group, 32 (19.6%) patients were treated with antibiotics. No difference was found between the groups (relative risk, 0.82; 95% confidence interval, 0.51-1.31; P = 0.49). Twenty-two (14%) patients in the intervention group were classified to have a possible infection according to the scale compared to 27 (17%) in the control group. No statistical difference was found (relative risk, 0.81; 95% confidence interval, 0.48-1.37; P = 0.54). CONCLUSIONS: Prophylactic cloxacillin as a single-dose IV in breast reduction surgery does not reduce the incidence of postoperative infections.
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Authors | Richard Lewin, Anna Elander, Andri Thorarinsson, Lars Kölby, Per-Erik Sahlin, Jonas Lundberg, Alexander Panczel, Mattias Lidén |
Journal | Annals of plastic surgery
(Ann Plast Surg)
Vol. 74
Issue 1
Pg. 17-21
(Jan 2015)
ISSN: 1536-3708 [Electronic] United States |
PMID | 25305230
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Clindamycin
- Cloxacillin
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Topics |
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
- Clindamycin
(therapeutic use)
- Cloxacillin
(therapeutic use)
- Drug Administration Schedule
- Female
- Follow-Up Studies
- Humans
- Incidence
- Injections, Intravenous
- Mammaplasty
- Middle Aged
- Prospective Studies
- Surgical Wound Infection
(epidemiology, prevention & control)
- Treatment Outcome
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