Scintigraphic detection of atherosclerotic plaques in rabbits with 111In-labeled hematoporphyrin derivative.

Abstract

The efficacy of 111In-labeled hematoporphyrin derivative (HPD) in localizing and detecting atheromas had been investigated with 10 atherogenic New Zealand white rabbits. Atherosclerotic plaques surgically induced in the abdominal aorta showed selective uptake of 111In-HPD over normal blood vessels averaging 0.01% ID/g tissue (range 0.003-0.023% ID/g). Normal aorta and thoracic artery concentrated an average of 0.0026% ID/g which is less than the mean blood activity of 0.0034% ID/mL. Statistical analysis demonstrated significant difference in the uptake of 111In-HPD by the atherosclerotic plaque segments as compared to normal abdominal aorta (P = 0.0023) and normal thoracic artery (P = 0.0012). In hypercholesteremic rabbits, the mean plaque segment to normal blood vessels ratio was 4:1 (range 2 to 9:1) sufficiently high to permit plaque delineation in the scintigram. Although 111In-HPD showed promise as a plaque imaging agent, further investigation with large animal models such as primates is needed to confirm current findings.

• Authors: D W Wong, S Hyman, I Reese, J E Brown, P Vasinrapee, R Siegler, S Giannotta
• Journal: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology (Int J Rad Appl Instrum B) Vol. 16 Issue 5 Pg. 511-7 ( 1989) ISSN: 0883-2897 [Print] England
• PMID: 2530194 (Publication Type: Journal Article)

Chemical References

• Hematoporphyrins
• Indium Radioisotopes
• Hematoporphyrin Derivative

Topics

• Animals
• Aorta, Abdominal
• Aortic Diseases (diagnostic imaging)
• Arteriosclerosis (diagnostic imaging)
• Female
• Hematoporphyrin Derivative
• Hematoporphyrins (pharmacokinetics)
• Indium Radioisotopes
• Rabbits
• Radionuclide Imaging
• Tissue Distribution