Association of brain-derived neurotrophic factor (BDNF) and elongator protein complex 4 (ELP4) polymorphisms with benign epilepsy with centrotemporal spikes in a Greek population.

Abstract

PURPOSE:

Benign epilepsy with centrotemporal spikes (BECTS) is considered to be the most common childhood epileptic syndrome. Different mutations in genes that control the excitability of neurons have been described. Recent reports on the involvement of the BDNF and ELP4 genes in cell motility, migration, and adhesion raise the possibility that these genes are involved in pathogenesis of BECTS.

MATERIALS AND METHODS:

We conducted a case-control association study on 60 patients with BECTS and 60 control participants to assess the influence of the BDNF and ELP4 polymorphisms on BECTS. The polymorphisms were detected with a PCR-RFLP method. Moreover, we explored the possible association of these polymorphisms with clinical and electroencephalographic parameters of patients with BECTS.

RESULTS:

Our results show no difference in BDNF and ELP4 genotype frequencies between patients and controls. Haplotype analysis also revealed no statistical difference.

CONCLUSION:

The role of BDNF and ELP4 polymorphisms remains controversial.

• Authors: Anastasia Gkampeta, Liana Fidani, Jordi Clarimón, Kallirhoe Kalinderi, Teodora Katopodi, Dimitrios Zafeiriou, Evangelos Pavlou
• Journal: Epilepsy research (Epilepsy Res) Vol. 108 Issue 10 Pg. 1734-9 (Dec 2014) ISSN: 1872-6844 [Electronic] Netherlands
• PMID: 25301525 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Brain-Derived Neurotrophic Factor
• ELP4 protein, human
• Nerve Tissue Proteins
• BDNF protein, human

Topics

• Brain-Derived Neurotrophic Factor (genetics)
• Case-Control Studies
• Child
• Child, Preschool
• Electroencephalography
• Epilepsy, Rolandic (genetics, physiopathology)
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Greece
• Haplotypes
• Humans
• Male
• Nerve Tissue Proteins (genetics)
• Polymorphism, Single Nucleotide