Abstract | INTRODUCTION: Patients with metastatic colorectal cancer can develop jaundice from intrahepatic or extrahepatic causes. Currently, there is little data on the underlying causes and overall survival after onset of jaundice. The purpose of this study was to characterize the causes of jaundice and determine outcomes. METHODS: Six hundred twenty-nine patients treated for metastatic colorectal cancer between 2004 and 2010 were retrospectively reviewed. Those developing jaundice were grouped as having intrahepatic or extrahepatic obstruction. Demographics, clinicopathologic, and outcome data were analyzed. RESULTS: Sixty-two patients with metastatic colorectal cancer developed jaundice. Intrahepatic biliary obstruction was most common, occurring in younger patients. Time from metastatic diagnosis to presentation of jaundice was similar between groups, as was the mean number of prior lines of chemotherapy. Biliary decompression was successful 41.7 % of the time and was attempted more commonly for extrahepatic causes. Median overall survival after onset of jaundice was 1.5 months and it was similar between groups, but improved to 9.6 months in patients who were able to receive further chemotherapy. CONCLUSIONS:
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Authors | Shawnn D Nichols, Scott Albert, Lawrence Shirley, Carl Schmidt, Sherif Abdel-Misih, Samer El-Dika, J Royce Groce, Christina Wu, Richard M Goldberg, Tanios Bekaii-Saab, Mark Bloomston |
Journal | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
(J Gastrointest Surg)
Vol. 18
Issue 12
Pg. 2186-91
(Dec 2014)
ISSN: 1873-4626 [Electronic] United States |
PMID | 25300799
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Colorectal Neoplasms
(complications, pathology)
- Decompression, Surgical
(methods)
- Female
- Follow-Up Studies
- Humans
- Jaundice, Obstructive
(diagnosis, etiology, surgery)
- Liver Neoplasms
(complications, diagnosis, secondary)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Tomography, X-Ray Computed
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