Abstract | BACKGROUND: RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B- catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.
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Authors | Laura García-Labastida, Raquel Garza-Guajardo, Oralia Barboza-Quintana, Irám Pablo Rodríguez-Sanchez, Jesús Ancer-Rodríguez, Juan Pablo Flores-Gutierrez, Gabriela Sofía Gómez-Macías |
Journal | Biological research
(Biol Res)
Vol. 47
Pg. 43
(Sep 18 2014)
ISSN: 0717-6287 [Electronic] England |
PMID | 25299496
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antigens, Differentiation
- Biomarkers, Tumor
- CDX2 Transcription Factor
- Homeodomain Proteins
- MUC2 protein, human
- Mucin-2
- Trans-Activators
- beta Catenin
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Topics |
- Adenocarcinoma, Mucinous
(chemistry, pathology)
- Adult
- Aged
- Aged, 80 and over
- Antigens, Differentiation
(analysis)
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(chemistry, pathology)
- CDX2 Transcription Factor
- Female
- Homeodomain Proteins
(analysis)
- Humans
- Immunohistochemistry
- Intestinal Mucosa
(chemistry)
- Middle Aged
- Mucin-2
(analysis)
- Retrospective Studies
- Trans-Activators
(analysis)
- beta Catenin
(analysis)
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