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CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast.

AbstractBACKGROUND:
Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma.
RESULTS:
Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2.
CONCLUSIONS:
These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.
AuthorsLaura García-Labastida, Raquel Garza-Guajardo, Oralia Barboza-Quintana, Irám Pablo Rodríguez-Sanchez, Jesús Ancer-Rodríguez, Juan Pablo Flores-Gutierrez, Gabriela Sofía Gómez-Macías
JournalBiological research (Biol Res) Vol. 47 Pg. 43 (Sep 18 2014) ISSN: 0717-6287 [Electronic] England
PMID25299496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antigens, Differentiation
  • Biomarkers, Tumor
  • CDX2 Transcription Factor
  • Homeodomain Proteins
  • MUC2 protein, human
  • Mucin-2
  • Trans-Activators
  • beta Catenin
Topics
  • Adenocarcinoma, Mucinous (chemistry, pathology)
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Differentiation (analysis)
  • Biomarkers, Tumor (analysis)
  • Breast Neoplasms (chemistry, pathology)
  • CDX2 Transcription Factor
  • Female
  • Homeodomain Proteins (analysis)
  • Humans
  • Immunohistochemistry
  • Intestinal Mucosa (chemistry)
  • Middle Aged
  • Mucin-2 (analysis)
  • Retrospective Studies
  • Trans-Activators (analysis)
  • beta Catenin (analysis)

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