Ceftaroline fosamil for the treatment of acute bacterial skin and skin structure infections in obese patients.

Abstract

BACKGROUND:

Ceftaroline fosamil is a broad-spectrum antibiotic approved by the US Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) and community-acquired bacterial pneumonia. The Clinical Assessment Program and Teflaro Utilization Registry (CAPTURE) is a multicenter registry study of patients treated with ceftaroline fosamil in the United States for ABSSSI or community-acquired bacterial pneumonia.

OBJECTIVE:

To describe the clinical effectiveness of ceftaroline fosamil in the treatment of ABSSSI in obese patients [body mass index (BMI) ≥ 30] compared with patients with a normal BMI (18.5 to ≤ 24.9).

METHODS:

Data were collected at US study centers by randomly ordered chart review.

RESULTS:

Data from 261 patients with a normal BMI and 690 patients with an obese BMI were collected. The percentage of males was higher in the normal BMI than in the obese category (58.2% and 49.0%, respectively). The mean and median ages at baseline were similar. Most patients (91%) were treated on a general hospital ward, and the mean and median lengths of stay were similar between the 2 groups (approximately 11 days and 7 days, respectively). A total of 73.2% of normal BMI patients and 77.5% of obese patients were discharged to home. Rates of diabetes mellitus were 26.4% in the normal BMI group and 55.1% in the obese group. Methicillin-resistant Staphylococcus aureus was isolated from 26.1% of normal BMI patients and 20.5% of obese patients (16.4% morbidly obese subset). Mean treatment duration for all patients was 5.9 days. Of patients with a normal BMI, 57.5% received ceftaroline fosamil as monotherapy as did 63.3% of obese patients. Clinical success was high in both the normal BMI (85.1%) and the obese (89.0%) groups.

CONCLUSION:

Ceftaroline fosamil is an effective treatment option for obese patients with ABSSSI with a similar clinical success rate, mean and median length of stay, and discharge destination to home when compared with normal BMI patients.

• Authors: John D Evans, George Udeani, Phillip Cole, H David Friedland
• Journal: Postgraduate medicine (Postgrad Med) Vol. 126 Issue 5 Pg. 128-34 (Sep 2014) ISSN: 1941-9260 [Electronic] England
• PMID: 25295657 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• ceftaroline fosamil

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Cephalosporins (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Length of Stay
• Male
• Middle Aged
• Obesity (epidemiology)
• Patient Discharge
• Retrospective Studies
• Sex Factors
• Skin Diseases, Bacterial (drug therapy, epidemiology)
• Socioeconomic Factors
• United States
• Young Adult