Association of schizophrenia with T102C (rs6313) and 1438 A/G (rs6311) polymorphisms of HTR2A gene.

Abstract

OBJECTIVE:

The aim of this study is to investigate whether there were any associations between the T102C and 1438 A/G polymorphisms of the 5-HT2A receptor gene and schizophrenia. We conducted a case-control study of the T102C and 1438 A/G polymorphisms in Turkish patients.

METHODS:

We compared genotypes and allele frequencies of T102C and 1438 A/G polymorphisms of 5-HT2A receptor gene in 102 patients with schizophrenia diagnosed, according to DSM-IV, and 107 healthy controls. Genotyping was performed by real-time polymerase chain reaction.

RESULTS:

We found no significant association between schizophrenia and genotypic or allele frequencies of HTR2A gene 102T/C (rs6313) and 1438 A/G (6311) polymorphisms. However, comparison of HTR2A gene 102 T/C and 1438 A/G polymorphisms in terms of genotypic and allele frequencies between the two patient groups, with or without a family history of schizophrenia, shows that T- and A-allele frequencies were significantly higher (p < 0.05) in the case group that has a history of schizophrenia in their family.

CONCLUSION:

In conclusion, our results do not support the hypothesis that the T102C and 1438 A/G polymorphisms in the 5-HT2A receptor gene are associated with schizophrenia, but further studies in a larger sample are needed.

• Authors: Saliha Handan Yildiz, Asli Akilli, Erman Bagcioglu, Mujgan Ozdemir Erdogan, Kerem Senol Coskun, Ahmet Hamdi Alpaslan, Burak Subasi, Evrim Suna Arikan Terzi
• Journal: Acta neuropsychiatrica (Acta Neuropsychiatr) Vol. 25 Issue 6 Pg. 342-8 (Dec 2013) ISSN: 1601-5215 [Electronic] England
• PMID: 25287874 (Publication Type: Journal Article)