Abstract | BACKGROUND/AIMS: METHODS: A tissue microarray was used to detect the expression level of AKR1B10 protein in tumors from 255 patients with hepatocellular carcinoma who underwent curative hepatectomy. The impact of AKR1B10 expression on the survival of patients was analyzed. The median follow-up period was 119.8 months. RESULTS: High AKR1B10 protein expression was observed in 125 of the 255 patients with hepatocellular carcinoma (49.0%). High AKR1B10 expression was significantly associated with a lack of invasion of the major portal vein (p=0.022), a lack of intrahepatic metastasis (p=0.010), lower the American Joint Committee on Cancer T stage (p=0.016), lower the Barcelona Clinic Liver Cancer stage (p=0.006), and lower α- fetoprotein levels (p=0.020). High AKR1B10 expression was also correlated with a lack of early recurrence (p=0.022). Multivariate analyses of survival revealed that intrahepatic metastases and lower albumin levels were independent predictors of both shorter recurrence-free survival and shorter disease-specific survival. High AKR1B10 expression was an independent predictor of both longer recurrence-free survival (p=0.024) and longer disease-specific survival (p=0.046). CONCLUSIONS:
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Authors | Sang Yun Ha, Dae Hyun Song, Jae Jun Lee, Hyun Woo Lee, Soo Youn Cho, Cheol-Keun Park |
Journal | Gut and liver
(Gut Liver)
Vol. 8
Issue 6
Pg. 648-54
(Nov 2014)
ISSN: 2005-1212 [Electronic] Korea (South) |
PMID | 25287169
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- AKR1B10 protein, human
- Aldo-Keto Reductases
- Aldehyde Reductase
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Topics |
- Adolescent
- Adult
- Aged
- Aldehyde Reductase
(metabolism)
- Aldo-Keto Reductases
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Hepatocellular
(metabolism, surgery)
- Disease-Free Survival
- Female
- Hepatectomy
- Humans
- Immunohistochemistry
- Liver Neoplasms
(metabolism, surgery)
- Male
- Middle Aged
- Prognosis
- Young Adult
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