Long-term treatment of acne with 20% azelaic acid cream.

Abstract

Preliminary clinical studies (2) proved the effectiveness of topical azelaic acid (AZA) in the treatment of acne vulgaris. During the period of 1982-86 we carried out two studies with 20% AZA cream in patients with acne to determine its clinical indications and therapeutic schedules. The first, open study was of 100 unselected patients of either sex, while a second group of 30 patients formed a part of a larger (309 patients) multicentre single-blind comparison of topical AZA vs. 5% benzoylperoxide (BPO) gel for the treatment of papulopustular acne. The rates of improvement obtained indicate that topical AZA can be considered an effective therapy chiefly for papulo-pustular acne, with a very good local tolerance.

• Authors: S Cavicchini, R Caputo
• Journal: Acta dermato-venereologica. Supplementum (Acta Derm Venereol Suppl (Stockh)) Vol. 143 Pg. 40-4 ( 1989) ISSN: 0365-8341 [Print] Norway
• PMID: 2528258 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study)

Chemical References

• Dicarboxylic Acids
• azelaic acid
• Benzoyl Peroxide

Topics

• Acne Vulgaris (drug therapy, pathology)
• Administration, Topical
• Adolescent
• Adult
• Benzoyl Peroxide (therapeutic use)
• Dicarboxylic Acids (administration & dosage, therapeutic use)
• Female
• Humans
• Male
• Multicenter Studies as Topic
• Time Factors