[Thyroid hormone resistance (THR): a case report].

Abstract

Thyroid hormone resistance is a syndrome characterized by a reduced response to thyroid hormone with different degrees of resistance at target tissues. We present the clinical features, physical findings, and study protocol in a woman with thyroid hormone resistance. An arginine to tryptophan mutation on the β isoform of the thyroid hormone receptor gene was demonstrated. Thyroid hormone resistance is an uncommon cause of thyroid dysfunction. It is necessary to perform an adequate study and confirmation to avoid an inadequate and ineffective treatment of this condition.

• Authors: Paloma Almeda-Valdés, Bernardo Pérez-Enríquez, Daniel Cuevas-Ramos, Iván Pérez-Díaz, María Teresa Tusié-Luna, Francisco Javier Gómez-Pérez
• Journal: Gaceta medica de Mexico (Gac Med Mex) 2014 Sep-Oct Vol. 150 Issue 5 Pg. 465-9 ISSN: 0016-3813 [Print] Mexico
• Vernacular Title: Resistencia a hormonas tiroideas (RTH). Reporte de caso.
• PMID: 25275849 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Thyroid Hormone Receptors beta

Topics

• Adult
• Female
• Humans
• Mutation
• Thyroid Hormone Receptors beta (genetics)
• Thyroid Hormone Resistance Syndrome (genetics, physiopathology)